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Hiroki Sakai Selected Research

Hemangiosarcoma (Angiosarcoma)

4/2022In vitro anticancer effects of alpelisib against PIK3CA‑mutated canine hemangiosarcoma cell lines.
12/2020Development of synthetic microRNA-214 showing enhanced cytotoxicity and RNase resistance for treatment of canine hemangiosarcoma.
1/2020Tenovin-6 induces the SIRT-independent cell growth suppression and blocks autophagy flux in canine hemangiosarcoma cell lines.
9/2019Tumour necrosis factor-related apoptosis-inducing ligand induces apoptosis in canine hemangiosarcoma cells in vitro.
8/2016Therapeutic potential of endothelin inhibitors in canine hemangiosarcoma.
7/2016Effects of inhibitors of vascular endothelial growth factor receptor 2 and downstream pathways of receptor tyrosine kinases involving phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin or mitogen-activated protein kinase in canine hemangiosarcoma cell lines.
10/2015MicroRNA-214 and MicroRNA-126 Are Potential Biomarkers for Malignant Endothelial Proliferative Diseases.
1/2015MicroRNA-214 Promotes Apoptosis in Canine Hemangiosarcoma by Targeting the COP1-p53 Axis.
7/2012Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines.
10/2009Establishment of canine hemangiosarcoma xenograft models expressing endothelial growth factors, their receptors, and angiogenesis-associated homeobox genes.
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Hiroki Sakai Research Topics

Disease

32Neoplasms (Cancer)
07/2022 - 09/2002
11Hemangiosarcoma (Angiosarcoma)
04/2022 - 03/2007
9Carcinogenesis
10/2015 - 09/2002
6Infections
03/2019 - 04/2006
5Adenocarcinoma of Lung
01/2022 - 01/2017
5Necrosis
09/2019 - 06/2009
4Spinal Cord Diseases
09/2021 - 01/2017
4Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2021 - 01/2017
3Hepatocellular Carcinoma (Hepatoma)
04/2022 - 11/2018
3Ganglion Cysts (Ganglion)
03/2018 - 06/2011
3Histiocytic Sarcoma
09/2015 - 10/2007
3Body Weight (Weight, Body)
12/2012 - 05/2006
2Granuloma
08/2022 - 01/2012
2Thrombosis (Thrombus)
01/2022 - 12/2019
2Lymphoma (Lymphomas)
05/2021 - 12/2018
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
03/2021 - 01/2017
2Neoplasm Metastasis (Metastasis)
01/2021 - 12/2018
2Cysts
03/2019 - 12/2011
2Inflammation (Inflammations)
10/2018 - 12/2016
2Melanoma (Melanoma, Malignant)
11/2015 - 06/2013
1Acute Cholecystitis
05/2022
1Liver Neoplasms (Liver Cancer)
04/2022
1Cholangiocarcinoma
04/2022
1Patent Foramen Ovale
01/2022
1Pain (Aches)
11/2021
1Postoperative Pain
11/2021
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
10/2021
1Hypoxia (Hypoxemia)
10/2021
1Erythema Multiforme
10/2021
1Disease Progression
09/2021
1Pulmonary Artery Stenosis
07/2021
1Neuroinflammatory Diseases
03/2021

Drug/Important Bio-Agent (IBA)

7Proteins (Proteins, Gene)FDA Link
01/2022 - 03/2007
6MicroRNAs (MicroRNA)IBA
03/2021 - 06/2013
4Biomarkers (Surrogate Marker)IBA
01/2022 - 10/2015
4CytokinesIBA
03/2021 - 12/2008
4CarcinogensIBA
08/2006 - 12/2002
3Superoxide Dismutase-1IBA
03/2021 - 01/2017
3LigandsIBA
12/2019 - 05/2016
3Phosphopyruvate Hydratase (Enolase)IBA
03/2018 - 06/2011
2DNA (Deoxyribonucleic Acid)IBA
06/2022 - 12/2012
2Messenger RNA (mRNA)IBA
04/2022 - 10/2018
2ProteomeIBA
01/2021 - 01/2019
2Ribonucleases (Ribonuclease)IBA
12/2020 - 06/2013
2Carboplatin (JM8)FDA LinkGeneric
01/2020 - 01/2017
2130-nm albumin-bound paclitaxelIBA
01/2020 - 01/2017
2Tumor Biomarkers (Tumor Markers)IBA
12/2019 - 01/2018
2Acetaminophen (Paracetamol)FDA LinkGeneric
10/2018 - 10/2018
2EnzymesIBA
10/2018 - 08/2008
2Pharmaceutical PreparationsIBA
10/2018 - 01/2013
2Prednisolone (Predate)FDA LinkGeneric
05/2018 - 09/2016
2TubulinIBA
03/2018 - 11/2011
2ErbB Receptors (EGF Receptor)IBA
01/2018 - 01/2017
2VimentinIBA
01/2017 - 11/2011
2Coloring Agents (Dyes)IBA
03/2015 - 01/2012
2AcidsIBA
09/2014 - 08/2008
2AntigensIBA
09/2014 - 04/2006
2Anti-Bacterial Agents (Antibiotics)IBA
01/2013 - 01/2012
2diisopropanolnitrosamineIBA
10/2007 - 07/2006
2Dimenhydrinate (DMH)FDA LinkGeneric
08/2006 - 06/2003
21,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA
08/2006 - 06/2003
1PolyestersIBA
08/2022
1PeroxiredoxinsIBA
07/2022
1RNA (Ribonucleic Acid)IBA
04/2022
1AlpelisibIBA
04/2022
1Immune Checkpoint InhibitorsIBA
12/2021
1CateninsIBA
11/2021
1Ephrin-A1 (Ephrin A1)IBA
10/2021
1Zonisamide (Zonegran)FDA LinkGeneric
10/2021
1Granzymes (Granzyme)IBA
10/2021
1CurcuminIBA
09/2021
1Complementary DNA (cDNA)IBA
05/2021
1platelet protein P47 (pleckstrin)IBA
05/2021
11-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride (DEP)IBA
05/2021
1ChemokinesIBA
03/2021
1Oncogene Proteins (Oncogene Protein)IBA
01/2021
1Aspartic Acid (Aspartate)FDA Link
01/2021
1Metformin (Glucophage)FDA LinkGeneric
01/2021
1petasinIBA
01/2021
1NucleotidesIBA
01/2021
1Phenformin (Fenformin)IBA
01/2021
1B7-H1 AntigenIBA
01/2021
1Fibroblast Growth Factor Receptors (Fibroblast Growth Factor Receptor)IBA
01/2020

Therapy/Procedure

4Drug Therapy (Chemotherapy)
05/2021 - 12/2018
4Oral Administration
01/2020 - 03/2007
4Therapeutics
12/2019 - 07/2013
3Hepatectomy
04/2022 - 03/2007
3Radiotherapy
07/2019 - 11/2015
2Operative Surgical Procedures
01/2020 - 05/2016
2Adjuvant Chemotherapy
01/2020 - 01/2017
2Craniotomy
03/2019 - 02/2018
1Laparoscopic Cholecystectomy
05/2022
1Segmental Mastectomy (Lumpectomy)
01/2022
1Lymph Node Excision (Lymph Node Dissection)
01/2022
1Embolectomy
01/2022
1Activities of Daily Living (ADL)
11/2021
1Anterior Cruciate Ligament Reconstruction
11/2021
1Pain Management
11/2021
1Lasers (Laser)
10/2021
1Norwood Procedures
07/2021